Different. By design. Centered in the bustling Cortex District, steps from award winning restaurants

Discover a bold new way to stay at Aloft St. Louis Cortex, where modern design and social spaces create the perfect backdrop for your St. Louis getaway. Unwind with craft cocktails and live music at our vibrant WXYZ bar, located in the heart of the Cortex Innovation Community. We're just minutes from Barnes-Jewish Hospital, St. Louis Children's Hospital, and SSM Health, plus top sports and entertainment at Busch Stadium and Enterprise Center. Explore iconic attractions like the Gateway Arch, St....

Discover a bold new way to stay at Aloft St. Louis Cortex, where modern design and social spaces create the perfect backdrop for your St. Louis getaway. Unwind with craft cocktails and live music at our vibrant WXYZ bar, located in the heart of the Cortex Innovation Community. We're just minutes from Barnes-Jewish Hospital, St. Louis Children's Hospital, and SSM Health, plus top sports and entertainment at Busch Stadium and Enterprise Center. Explore iconic attractions like the Gateway Arch, St. Louis Zoo, and Forest Park, all less than a mile away. Convenient parking options include valet and self-parking in the North Duncan lot next to the hotel. Fuel your day with our cooked-to-order breakfast before heading out to explore nearby favorites including the Missouri Botanical Garden, Anheuser-Busch Brewery, Saint Louis Science Center, Chaifetz Arena, Fox Theatre, Saint Louis University, & Washington University. At Aloft St. Louis Cortex, your stay is as dynamic as the city itself.