Discovery in the era of targeted agents requires that patients be identified early in treatment so that they can be matched to the optimal compound. By integrating an oncology research network with an oncology focused CRO and data services group, ACORN Research is uniquely designed to support research demands in the era of personalized oncology. The ACORN Data Repository contains clinical data from participating research sites and is an ideal platform to conduct study feasibility, trial-matching, and other queries. Additionally, this data can be linked to biospecimens collected from these research sites.