The well-being of guests is top of mind at Choice-branded hotels. Guests may experience a variety of new, improved cleanliness protocols and products. Get more of the space you need to spread out, relax or work at the smoke-free Comfort Suites Jackson-Cape Girardeau hotel in Jackson, MO off Interstate 55. Nearby destinations include Southeast Missouri State University, Shawnee Park Sports Complex, Riverfront Park of Cape Girardeau, Trail of Tears State Park and Southeast Missouri Hospital. Enjoy amenities like free hot breakfast, free WiFi, fitness center, business center and indoor heated pool. Spacious suites include HDTV, refrigerator, microwave, hair dryer, sofa sleeper and recharge device. Also, earn rewards including free nights and gift cards with our Choice Privileges Rewards program.