Creative Bioarray provides a wide range of high quality normal human and animal cells, cell culture medium and reagents, FISH probes, tissue array, microorganisms, equipments and related services for the research community.

RNA interference has become a widely used approach to perform gene knockdown experiments in cell cultures and more recently transgenic animals. It has developed into a routine method to assess gene function in a fast and easy manner. Since 2008, Creative Animodel's scientists have generated more than 200 RNAi models for innovative biomedical researchers. These RNAi models allow researchers to induce and reverse gene knockdown in transgenic mice at selected time points in vivo. We have developed RNAi-mediated gene knockdown mice by: Silencing lentiviral vectors and adenoviral vectors Transgenic mice can be generated rapidly by transduction of early embryos with lentiviral silencing vectors and adenoviral vectors, resulting in mice with down regulated target genes. These methodologies offer the possibility of large-scale generation of knockdown transgenic mice for functional genomic studies and enable the production of transgenic mice in 7 weeks. Cre/loxP system as an activate RNAi in a time- and tissue-dependent manner Single-copy RNAi constructs are placed into the Rosa26 locus of ES cells by recombinase-mediated cassette exchange and transmitted through the germline of chimaeric mice. The site-specific insertion of single-copy shRNA vectors allows the expedite and reproducible production of knockdown mice and provides an easy and fast approach to assess gene function in vivo.

The human leukocyte antigen (HLA) system is the locus of genes that encode for proteins on the surface of cells that are responsible for regulation of the immune system in humans. The genes encoding these antigens are the most varied in humans and it is well established that an individual's HLA profile determines their capacity to mount a protective immune response to a foreign protein. There are many thousands of different HLA types and thus the capacity to mount an immune response can be dramatically different between individuals within a cohort selected from a single population. The HLA region can provide critical insight into various diseases and situations .