Our technology uses aligned and randomly oriented polymer nanofibers integrated into standard multi-well cell culture dishes and can be easily scaled up for larger bioreactor systems. Our products allow researchers to perform high-throughput tests involving cell migration/invasion, drug discovery, in vitro diagnostics, and stem cell expansion and differentiation. The products have the same general size and shape of standard cell culture dishes allowing ease of acceptance and compatibility with automated systems. They provide a 3-D topography that mimics the in vivo topography and are optically transparent to allow for live-cell imaging and real time quantification of cell mobility.