Wysox Township is located within the central region of the County. It is bound in the north by Rome Township to the northeast by Orwell and Herrick Township, to the east by Standing Stone Township, to the south by Asylum Township, to the southwest by Towanda Township and Borough, and to the northwest by Sheshequin Township. The Susquehanna River serves as the Townships south boundary between Asylum Township. There are several other streams that flow through the Township which include: Wysox Creek, Laning Creek, Hollow Run, Dry Run, and Vought Creek. The major thoroughfares in the Township include: State Route 187, US Route 6, and Mercur Hill Road. The Township of Wysox was established in 1795 from Tioga Township. The name is derived from old Native American words that include: "Wisachgimi