Dr. Anne Arnett and her research team aim to improve precision medicine care for children and families affected by neurodevelopmental disorders. Dr. Arnetts laboratory investigates brain-behavior associations leading to atypical neurodevelopment among children. Research initiatives have included investigations of neurocognitive and genetic etiologies of ADHD, learning disorders and autism; as well as single gene disorders associated with autism and intellectual disability.

Boston Children's in Boston, MA has always embodied a culture of innovation and scientific discovery, with the goal of improving the lives of children and families. This legacy continues today as we lead the world in pediatric research, empowering our clinicians and scientists to challenge the status quo and seek better answers for children everywhere.

Our work involves the characterization of the multi-scale influence of genetic variation on basic physiology, brain networks, neurocognition, and on the complex clinical features and common comorbidities observed in affective and psychotic disorders. Interpretation of such findings is predicated on a clear understanding of the genetic control of normal neuroanatomic, neurophysiologic and cognitive variation, particularly since genes influencing normal variation are often also associated with pathology. Therefore, a major component of our research focuses on determining the genetic aspects of individual differences.

The Boston Childrens Hospital Laboratory for Molecular Pediatric Pathology (BCH LaMPP) provides highly innovative tissue-based diagnostic testing, uniquely tailored to serve pediatric patients, particularly those with cancer and developmental anomalies associated with tumor-like tissue overgrowths. The core technologies of the laboratory are focused on solid-state high-throughput genomic sequencing, rare mutation detection and copy number analysis.

The broad interests of the Cantor Laboratory are to elucidate the gene regulatory mechanisms involved in normal blood cell development and to understand how their dysregulation leads to certain human blood disorders. This involves studies of hematopoietic transcription factors, chromatin remodeling complexes, epigenetics, chromatin architecture, signal transduction, stem cell self-renewal, cell fate decisions and terminal cell maturation. Our work pertains to human leukemias, myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPNs), congenital dyserythropoieitic anemias/thrombocytopenias, sickle cell disease, and thalassemia.

Boston Children's in Boston, MA has always embodied a culture of innovation and scientific discovery, with the goal of improving the lives of children and families. This legacy continues today as we lead the world in pediatric research, empowering our clinicians and scientists to challenge the status quo and seek better answers for children everywhere.

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The overall goal of the Sampson Lab is to help improve the health of children with nephrotic syndrome through applied genomics, with a focus on samples and data collected from patients with this condition. We use computational genomics and bioinformatics to discover new, and map known, nephrotic syndrome-associated variants. We use systems genomics to integrate this genetic data with other genome-scale molecular datasets to try to understand the mechanisms linking these genetic changes with disease. And we use epidemiology to discover the clinical consequences for patients carrying disease-associated genetic variants.

The Weitzman Lab focuses on improving the health and healthcare of children, adolescents and young adults through understanding and ameliorating the psychosocial, medical and behavioral problems affecting them. We advance high impact research that improves the lives of youth placing emphasis on the experiences and preferences of youth. Using a multidisciplinary team science approach, we address key issues, leveraging information technologies, big data, participatory, narrative and experimental methods.

Boston Children's in Boston, MA has always embodied a culture of innovation and scientific discovery, with the goal of improving the lives of children and families. This legacy continues today as we lead the world in pediatric research, empowering our clinicians and scientists to challenge the status quo and seek better answers for children everywhere.

The Institutional Centers for Clinical and Translational Research (ICCTR) at Boston Children's Hospital enables investigators to make significant contributions to the improvement of children's health. ICCTR's primary mission is to support Boston Children's investigators through step-by-step guidance on planning, designing, implementing, and reporting clinical and translational studies.

The Snapper Laboratory is located in the division of GI/Nutrition in the Enders Research Building at Boston Childrens Hospital. Our lab is a part of a larger consortium of talented interdisciplinary investigators that focus on gastrointestinal research. The Snapper lab is interested in the cellular and molecular mechanisms of mucosal immunity and host-microbial cross-regulation that promote immune homeostasis and gastrointestinal health. In effort to understand human gastrointestinal inflammatory disorders, we have established a research pipeline that moves our basic research findings into novel translational models which funnel into new clinical trials.